The role of oxidative stress in determining prognosis in children with FMF and the relationship between markers of oxidative stress and gene mutation
نویسندگان
چکیده
Background Uncontrollable neutrophil activation and its migration to serous tissues that result in oxidative stress responsible for the tissue damage due to pyrin mutation in FMF patients. Reactive oxygen radicals are released by active neutrophils and the basic cell compounds such as nucleic acids, proteins and lipids during the inflammation. The aim of our study was to measure plasma advanced oxidation protein product (AOPP) and serum amyloid A (SAA) in children with FMF and to investigate the relationship with clinical findings and gene mutations as well.
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